Windows 10/11 Memory Integrity/Core Isolation Disables Driver Installation
Some users have reported getting an error message when installing Line 6 product drivers on Windows 10 or 11. The error message will mention that Line 6 drivers are not being recognized or are being blocked after installation.
The best workaround for this is to disable Memory Integrity under Windows security settings. You can find this feature under Windows Security > Device Security > Core Isolation details.
See this article from Microsoft for further details:
This is a known issue to our team, and for now the best option is to disable Memory Integrity as a work-around. We will continue to monitor this issue for our driver releases.